PIK3CA and colorectal carcinoma: To facilitate selection of cell lines as appropriate research models, we performed gene expression enrichment analysis of eight gene sets representing important pathways or processes in CRC, including ERK/MAPK, PI3K/AKT, EGFR, TGFß and WNT signaling, in addition to signatures of epithelial to mesenchymal transition, citric acid cycle activation and the gastro-intestinal signature (Fig. 6a; Additional file 1: Table S14).