There are 24 variables not associated with prior hospitalization, which included age at baseline visit, sex, living situation, regular care partner, certainty of PD diagnosis, rest tremor presence, motor fluctuations, Hoehn and Yahr stage, disease duration, PDQ -39 emotional well-being, PDQ-39 total score, number of medications before baseline visit, dopamine agonist, MAO-B inhibitor, COMT inhibitor, amantadine, cognitive enhancers, stimulants, antipsychotics, anticholinergics, occupational therapy, speech therapy, exercise program, and social worker/counseling. This evidence concerns the gene COMT and Parkinson disease.