SOD1 and triple-A syndrome: Besides, the SOD activity is increased in UCP-2+/+ApoE-/- mice as compared with WT mice, whereas deficiency of UCP-2 decreased the increasing SOD activity in Ang-II treated ApoE-/- mice (Fig 3D), indicating that the antioxidant defense is impaired due to UCP-2 deficiency, and leading AAA formation.