The apolipoprotein ε4 allele (APOE ε4 allele) it is strongly associated with detrimental outcomes to adult health including high cholesterol [1], atherosclerotic disease [2,3,4], reduced lifespan [5,6] and Alzheimer’s disease (AD) [3,7,8]. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.