MELK and HIV-1 infection: Overexpression of MELK but not the MELK mutant inhibited HIV-1 infection (Fig 6C, compare CSII-control, CSII-MELK and CSII-MELK T167A) and resulted in aberrant viral cDNA synthesis quite similar to the S149E CA mutant (Fig 6D, compare CSII-Control, CSII-MELK and CSII-MELK-T167A).