ADIPOQ and major depressive disorder: Recent studies have shown that impairment of the normal structure and function of microglia, caused by autoimmune diseases, can result in depression and associated impairments in neuroplasticity and neurogenesis[19] and interferon-α-induced activation of microglia was particularly relevant to depressive-like behavior.[20] Additionally, a study in mice suggested that enriched environment-induced Adiponectin increase within the brain regulates microglia and brain macrophages phenotype and activation state, thus reducing neuroinflammation and depressive-like behaviors in mice.[21]