PTPN2 and cancer: In the previous study, we have reported that PtPT synthesized in our lab could produce tumor tissue-specific inhibition of proteasome-associated DUBs and tumor-specific toxicity, showing clinical significance for designing novel strategies for cancer treatment.35 Here, consistent with findings derived from studies using other cancer cells, PtPT induced UPS inhibition in both Bcr-Abl wild-type and Bcr-Abl T315I cell lines, as well as in primary mononuclear cancer cells derived from CML patients including IM-sensitive and -resistant cells.