Only recently we have defined that a new platinum-based antitumor agent platinum pyrithione (PtPT), the platinum ion and PT-chelating product has inhibitory activity of 26 S proteasome-associated DUBs and thereby exerts safer and potent antitumor effects.35 In the present study, we investigated the antineoplastic effects of PtPT on Bcr-Abl wild-type and Bcr-Abl-T315I mutant cell lines, primary cells from CML patients and mouse IM-resistant xenograft models. Here, PTPN2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.