In addition, we found that PtPT treatment at doses from 0.5 to 3.0 μM for 36 h resulted in significant apoptosis in all the primary monocytes from the 10 CML patients as detected with Annexin V/PI double staining (Figure 3e, right). The gene discussed is PTPN2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.