PTPN2 and chronic myelogenous leukemia, BCR-ABL1 positive: As displayed in Figure 3c, PtPT decreased the cell viability of primary monocytes from CML patients with IC50 values ranging from 0.22 μM to 1.10 μM (0.68±0.3 μM), while for the mononuclear cells from six healthy volunteers, the IC50 values were more than 4.4 μM as we reported recently, approximately 6.5 times higher than that for primary monocytes obtained from CML patients.27