PTPN2 and cancer: In the in vitro study, PtPT dose- and time-dependently causes significant mitochondrial damage and apoptosis in both IM-sensitive and IM-resistant CML cells; in the mononuclear cancer cells from CML patients, PtPT also decreased cell viability and induced cell death; in the in vivo experiment, the growth of both IM-sensitive and -resistant xenografted tumor cells were inhibited by PtPT treatment.