Accordingly, besides Aβ, AICD and other APP fragments accumulate in brains from individuals with Trisomy 21 (Sun et al., 2006), in brains of humans diagnosed with AD (Willem et al., 2015; Ghosal et al., 2009) and in APP over-expressing AD mouse models (Willem et al., 2015; Lauritzen et al., 2012). The gene discussed is APP; the disease is Alzheimer disease.