Akt2 ablation accentuated aging‐induced cardiac hypertrophy (58.2% in heart weight, 57.7% in heart‐to‐body weight, and 52.1% in heart‐to‐tibial length ratios compared to old WT mice) and hepatomegaly (20.1% rise compared to young WT mice) without affecting aging‐induced responses on kidney and spleen (organ weights or sizes). The gene discussed is AKT2; the disease is cardiac hypertrophy.