Six mediators were detectable in the supernatant (Fig. 2), of which only the secretion levels of IL-8, IP-10, and G-CSF were significantly increased by one or multiple Henipavirus strains following infection of hOE, by day 3 p.i. IL-8 was significantly increased in hOE infected with HeV compared to controls, but not with NiV-B or NiV-M (P < 0.05; 2-way analysis of variance [ANOVA]). This evidence concerns the gene CXCL8 and infection.