The altered expression of the neurotrophins and p75NTR in experimental models of peripheral nerve injury and in a range of human peripheral neuropathies (Yamamoto et al., 1998) has resulted in speculation that the neurotrophins could be involved in the pathogenesis and repair of these diseases (Pittenger and Vinik, 2003; Anand, 2004; Zhou and Notterpek, 2016). This evidence concerns the gene BDNF and peripheral neuropathy.