We have shown that neither injection of p75NTR antisense oligonucleotides nor the genetic knockout of p75NTR impedes the induction of experimental autoimmune encephalomyelitis (Soilu-Hanninen et al., 1999), a T-cell-mediated autoimmune disease in the CNS that has similar pathogenesis to EAN in the PNS. The gene discussed is NGFR; the disease is experimental autoimmune encephalomyelitis.