In chronic myeloid leukemia (CML), these receptors are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche, since deficiency of E-selectin and L-selectin in the bone marrow endothelium of mice significantly reduced the engraftment of BCR-ABL1-expressing stem cells, while P-selectin was not required [138]. This evidence concerns the gene SELL and chronic myelogenous leukemia, BCR-ABL1 positive.