Bioactive peptides exert anti-tumor activity via several key mechanisms: (a) Apoptosis induction, which involves an energy-dependent cascade mediated via specific proteases or caspases; strategies to overcome tumor resistance to apoptotic pathways include activation of pro-apoptotic receptors, restoration of p53 activity, caspase modulation, and proteasome inhibition (Burz et al., 2009). This evidence concerns the gene TP53 and neoplasm.