In accordance, during the infection of macrophages with Mycobacteria and Salmonella, Nramp1 promotes acidification and fusion with endosomal and lysosomal vesicles thereby generating a bactericidal environment for the pathogenic bacteria (Hackam et al., 1998; Govoni et al., 1999; Frehel et al., 2002; Jabado et al., 2003). This evidence concerns the gene SLC11A1 and infection.