SIRT3 and pulmonary arterial hypertension: reported metabolic remodeling in pulmonary endothelial cells with reduced BMPR2 expression, though manifestation of the PAH phenotype required exposure to hypoxia, implicating HIF but not SIRT3.50,54 Our findings fill in important gaps within and between these studies by providing a possible mechanism by which all of these published findings could be consistent with one another.