SIRT1 and optic neuritis: Our previous studies show significant RGC neuroprotective effects mediated by compounds that activate SIRT1 (Sirtuin 1, silent mating type information regulation 2 homolog) in both EAE- and mouse hepatitis virus-induced optic neuritis [11, 13, 14, 48] and similar neuroprotective effects of SIRT1 overexpression in a traumatic optic nerve injury model [49].