BACE1 and Alzheimer disease: The β-secretase, as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a rate-limiting enzyme that modulates Aβ production [3, 4], and overproduction of Aβ peptides is known to self-assemble into dimers and high molecular weight oligomers to form fibrils [5–7] that induce neurotoxicity and contribute to AD symptoms [8–10].