ACHE and Alzheimer disease: As cholinergic deficit is observed in the early stages of AD and associated with memory deficits, 10 μM wogonin (1/10 IC50) significantly inhibited AChE activity in Tet-On Aβ42-GFP SH-SY5Y neuroblastoma cells, suggesting that wogonin disrupted the activation of AChE induced by Aβ42.