Increased mRNA expression of the RyR2 has also been shown in a rat model of obesity (Lima-Leopoldo et al., 2008; Leopoldo et al., 2011), and further underscores an important role for RYRs in ventricular arrhythmias associated with metabolic disorders. The gene discussed is RYR2; the disease is obesity due to melanocortin 4 receptor deficiency.