In rats fed a high-fat diet for 8 weeks, obesity increased mRNA levels of ventricular expression of RyR2 (Ashrafi et al., 2016), while Leopoldo et al. showed increased expression in obese rats at 30 weeks and no change of expression at 15 and 45 weeks (Lima-Leopoldo et al., 2013). The gene discussed is RYR2; the disease is obesity due to melanocortin 4 receptor deficiency.