Searches were free texts and included the following keywords: “high fat diet,” “ion channel,” “obesity,” “metabolic syndrome,” “LQTS,” “atrial fibrillation,” “dyslipidemia,” “cardiac calcium channel,” “cardiac potassium channel,” “cardiac sodium channel,” “Ca handling proteins,” “NCX,” “pro-inflammatory cytokines,” “insulin,” “leptin,” “hyperglycemia,” and “hyperuricemia.” Despite our thorough search, it is also possible that we may have missed relevant studies including non–English language studies. The gene discussed is KCNA5; the disease is hyperuricemia.