Notably, loss-of-function mutations of either DAP12 or TREM2 result in a disorder known as Nasu-Hakola disease (NHD); and mutations of these genes have been associated with the risk for Alzheimer’s disease (AD), suggesting that TREM2 and DAP12 may regulate common signaling pathways in the disease pathogenesis. The gene discussed is TREM2; the disease is Alzheimer disease.