DLG1 and schizophrenia: DLG1, also referred to as synapse-associated protein 97 (SAP97), encoded by the SAP97 gene, has been well-documented to bind to neuroligin and glutamate receptor type 1, a member of the glutamate-gated ion channel family, resulting in disturbance of the glutamate neurotransmission system, an important signaling system implicated in the pathology of schizophrenia (Mefford et al., 2008; Zhou et al., 2008; Howard et al., 2010; Ikeda et al., 2010; Mulle et al., 2010; Nash et al., 2010; Yuan et al., 2014).