Studies have shown that the CNVs at 15q13.3 can disrupt the expression and function of the human α7 neuronal nicotinic acetylcholine receptor gene, an important gene highly expressed in the central nervous system and closely correlated to multiple mental disorders with cognitive impairments, including schizophrenia, by mediating rapid signal transmission at synapses (Sinkus et al., 2015). Here, IGKV2D-24 is linked to mental disorder.