NRXN1 and schizophrenia: For example, the schizophrenia-associated CNV deletion at 2p16.3 has been shown to disrupt NRXN1 gene, a member of the neurexin family, because the promoter and first exon of the NRXN1 gene fall within the interval of the CNV (Kirov et al., 2008, 2009; Malhotra and Sebat, 2012).