The genes disturbed by the CNVs mainly involve the SH2B1, TUFM, ATP2A1, and ATP2A2 genes, of which mutations of the single ATP2A2 gene in Darier disease have been found to be connected to the neuropsychiatric abnormalities frequently observed in Darier disease (Gordon-Smith et al., 2010). The gene discussed is SH2B1; the disease is Darier disease.