BAG3 has been reported to act in concert with the HSP70 chaperone in controlling cancer cell signaling; thereby, the HSP70-BAG3 complex was found to modulate the activity of various proteins, such as the transcription factors NF-κB, FoxM1 and Hif1α, the translation regulator HuR and the cell-cycle regulators p21 and survivin. The gene discussed is BAG3; the disease is cancer.