ALS-linked mutant forms of SOD1, such as SOD1G85R or SOD1G93A, have been shown to be selectively degraded by BAG3-mediated selective macroautophagy (Crippa et al., 2010b, 2013; Gamerdinger et al., 2011b). This evidence concerns the gene BAG3 and amyotrophic lateral sclerosis.