YWHAQ and neurodegenerative disease: Intriguingly, 14-3-3 proteins have been found to be part of inclusion bodies in a number of neurodegenerative diseases, proposing a role of 14-3-3 in promoting the formation of aggresomes during neurodegeneration (Zhao et al., 2011; Xu et al., 2013; Jia et al., 2014; Aghazadeh and Papadopoulos, 2016).