BAG3 and dilated cardiomyopathy: Mutations in the bag3 gene are associated with the development of severe diseases, such as myofibrillar myopathy or dilated cardiomyopathy (see Impact of BAG3 on Myopathies) (Selcen et al., 2009; Arimura et al., 2011; Norton et al., 2011; Villard et al., 2011; Lee et al., 2012).