BAG3 and neuroblastoma: In response to the fibroblast growth factor 2 (FGF2), BAG3 expression is positively modulated in neuroblastoma and neuronal progenitor cells; in this context, it could be demonstrated that the activation of bag3 in neuroblastoma cells is mediated by stimulation of the transcription factor EGR-1 (early growth response protein 1) (Gentilella et al., 2008; Gentilella and Khalili, 2010).