Interestingly, the cleavage product of the AD-associated amyloid β precursor protein sAβPPα was recently observed to negatively modulate BAG3-mediated aggresome formation; it was able to inhibit the stress-induced upregulation of BAG3 and to enhance proteasomal activity in the cell (Renziehausen et al., 2015; Kundu et al., 2016). This evidence concerns the gene BAG3 and Alzheimer disease.