fALS are linked to specific gene mutations (e.g., superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused-in-sarcoma/translocated-in-liposarcoma (FUS/TLS), Sequestosome-1 (SQSTM1/p62), Optineurin (OPTN-1), Ubiquilin (UBQLN-2), Valosin Containing Protein (VCP), TANK Binding Kinase 1 (TBK1) and several others (see Taylor et al., 2016 for review). The gene discussed is SQSTM1; the disease is sarcoma.