CHEK2 and breast cancer: In addition, the genes CHEK2, ATM, PALB2 (the partner and localizer of the BRCA2 gene) BRIP (BRCA1-interactingprotein gene), and NCOA3 (Nuclear Receptor Coactivator 3) are considered as predisposing genes increasingthe risk of BC (Jahani & Ghotbi 2002).