This process may be able to accelerate tumor progression acting on two distinct levels: 1) by inducing the phenotypic switch of less aggressive tumor cells by transferring the functional properties associated to metastatic behavior; 2) by affecting endothelial stability for the loss of VE-cadherin membrane localization with consequent endothelial hyperpermeabilty (Fig. 10). Here, CDH5 is linked to neoplasm.