BRCA1 and breast cancer: Previously identified LGRs include BRCA1/ex10dup and amplification of BRCA1 exons 3, 5 and 6 in Chileans22, BRCA1/ex9-12del in Mexican Americans18, BRCA1/ex8-9dup17, BRCA1/ex18-19del, and BRCA1/ex8-10del in Mexicans17, BRCA2/ex1-2del in Costa Ricans23, BRCA1/ex8-9del found in Bahamians24 and BRCA2/ex14del detected in male breast cancer patients from Brazil25.