Furthermore, silencing of RBM47 in DLD1, HT29, and HCT15 CRC cells resulted in repression of the epithelial-associated mRNAs E-cadherin (CDH1), OCLN, CLDN1, CLDN3, and ZO-1, as well as induction of the EMT-inducer SNAIL in DLD1 and HCT15 cells (Fig. 7b and c). This evidence concerns the gene CLDN1 and colorectal carcinoma.