Although we found that cytoplasmic and not nuclear DNA activated the AIM2/IFI205 sensing pathway, a previous study showed that the integrase inhibitor raltegravir exacerbated the autoimmune phenotype in two different autoimmune models: (NZB × NZW)F1 mice, which are predisposed to glomerulonephritis, and NZB mice, which are predisposed to autoimmune hemolytic anemia (42). Here, AIM2 is linked to autoimmune hemolytic anemia.