BDNF and juvenile Huntington disease: LM22A-4 treatment was shown to promote motor recovery after hypoxic-ischemic stroke in mice (Han et al., 2012), improve motor impairment in the mouse model of Huntington's disease (Simmons et al., 2013), enhance the recovery of limb function after spinal cord injury in mice (Yu and Wang, 2015), reduce alcohol intake in the mouse model of BDNF polymorphism-related compulsive alcohol drinking (Warnault et al., 2016) and ameliorate respiratory abnormalities in a mouse model of RTT (Kron et al., 2014; Schmid et al., 2012).