For example, human endometrial cancer could be inhibited by blocking the Kca3.1 [16]; balloon catheter delivery of TRAM-34 locally could prevent coronary artery VSMC phenotypic switching and reduce subsequent restenosis [30]; benign prostatic hyperplasia could be suppressed by blockage of Kca3.1 [31], and renal fibrosis is significantly attenuated by targetted interference of Kca3.1. This evidence concerns the gene KCNN4 and benign prostatic hyperplasia.