HMOX1 and neoplasm: In addition, when we included the combined NGF/HO1 expression pattern instead of individual expression of NGF and HO1 in multivariate analysis, tumor stage (OS; p < 0.001, RFS; p < 0.001), venous invasion (OS; p = 0.005, RFS; p = 0.007), and the co-expression pattern of NGF and HO1 (OS; overall p = 0.002, RFS; overall p = 0.003) were independent indicators of poor prognosis of gastric carcinoma patients (Table 3).