Looking moredeeply into the data collected in 2K1C model, the renin-angiotensin-aldosteronesystem (RAAS) is the primary factor in the development of hypertension.13 In hypertension, there is anactivation of the RAAS and in turn, a greater inhibition of kallikrein-kinin system(CMS) by ACE,14,15 this can result in a smaller reduction in SBPinduced by the Sclareol in the hypertensive group. The gene discussed is KLK4; the disease is hypertensive disorder.