Indeed, theadjustment for fatty liver is very important since we had previously shown a strongand independent association of hepatic steatosis, a highly active visceral fatdepot, with elevated plasma CRP levels independently of markers of obesity inapparently healthy subjects.9Another point of interest in the current study was that most individuals had milddepressive symptoms. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.