In this study, we examined the mutation distributions of 12 genes and microsatellite instability according to age group (<50, 50–60, 60–70, 70–80, and >80 at diagnosis of CRC) among 1475 cases of CRC after exclusion of 30 CRC patients who had definite evidence of mismatch repair genes (MMR) germline mutation (Lynch syndrome). This evidence concerns the gene MRC1 and colorectal carcinoma.