BRAF and colorectal carcinoma: In contrast to some studies suggesting that promoter methylation of CpG islands (CIMP-H) plays a minor role in the neoplastic progression of early onset of colorectal carcinoma due to rare BRAF mutations in young patients [11,30], our study showed that young patients still had 4.8% incidence of BRAF mutation, which was similar to those of other age groups.