IL10RA and colitis: However, C57BL/6 mice that specifically lack IL10Rα in MΦs (e.g. Il10rafl/flLyz2Cre mice) either do not reliably develop colitis (Li et al., 2015) or do so with a prolonged latency (e.g. Il10rafl/flCx3cr1Cre mice) (Zigmond et al., 2014).