IL10RA and inflammatory bowel disease: Given the rapid developmental changes in intestinal physiology, immune system responsiveness, diet, and the microbiome that occur during the first weeks of life (Arrieta et al., 2014; Pantoja-Feliciano et al., 2013), characterizing the function of IL10R signaling during this period could reveal fundamental regulatory processes that are essential to preventing IBD in infancy, and may aid our understanding of the pathological mechanisms driving IBD in general.