Consistent with previous work suggesting that IL10R signaling in MΦs prevents excessive lower bowel inflammation in various models (Li et al., 2015; Shouval et al., 2014b; Zigmond et al., 2014), the onset of intestinal inflammation in 3 week old Il10rb-/- mice was associated with increased numbers of LP MΦs, as well as an inversion in the ratio of newly recruited P1/P2 MΦ populations and resident P3/P4 MΦs. The gene discussed is IL10RA; the disease is inflammation.