CD4 and colitis: Although it is clear that IL10R signaling strongly inhibits a group of inflammation-induced genes, the ability of a relatively small number of adoptively transferred IL10R-sufficient MΦs to suppress the development of colitis in Rag2-/-Il10rb-/- mice reconstituted with CD4+ T cells (Shouval et al., 2014b) suggests that WT MΦs exert a dominant effect over IL10R-deficient MΦs.