The mRNA level ratios of SRSF1-RNAi (MOI5) over untreated (MOI0) were further plotted to assess the net impact of the SRSF1-RNAi on each cellular compartment and control or C9ORF72-ALS iNeurons (Fig. 8g). The gene discussed is SRSF1; the disease is amyotrophic lateral sclerosis.