Whilst the depletion of SRSF1 did not affect the total level and biogenesis/stability of intron-1-retaining transcripts in control or C9ORF72-ALS iNeurons, it specifically triggers a cytoplasmic reduction and nuclear accumulation of pathological C9ORF72 repeat transcripts in C9ORF72-ALS iNeurons (Fig. 8h,i). The gene discussed is SRSF1; the disease is amyotrophic lateral sclerosis.