Transduction of human iNPC (induced neural progenitor cells)-differentiated astrocytes (iAstrocytes) using a viral multiplicity of infection (MOI) of 5 led to efficient transcript knockdown comparable to levels achieved in vivo in neuroprotected G4C2x36+SRSF1-RNAi Drosophila (Supplementary Fig. 2a). The gene discussed is SRSF1; the disease is infection.