In order to investigate the nuclear export of C9ORF72 transcripts in the context of wild-type and repeat-expanded C9ORF72 genes, we differentiated motor neurons from established induced-neural progenitor cells (iNPCs) derived from sex/age matched control and C9ORF72-ALS patient fibroblasts52. Here, C9orf72 is linked to amyotrophic lateral sclerosis.