Consistent with our previous data presented in Drosophila and neuronal cells models, we also found that depletion of SRSF1 in C9ORF72-ALS patient-derived iMNs leads to specific reduction in the expression levels of poly-GP DPRs although it appears less efficient in C9ORF72-ALS patient 78 (Fig. 8d). Here, SRSF1 is linked to amyotrophic lateral sclerosis.