Remarkably, however, the transduction of SRSF1-RNAi lentivirus in iMNs prior to co-cultures with C9ORF72-ALS iAstrocytes resulted in significantly higher survival of iMNs against the astrocytic-derived toxicity (Fig. 8c) indicating a neuroprotective effect of SRSF1 depletion in motor neurons derived from C9ORF72-ALS patients. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.