It has to be acknowledged, however, that the most recent study has shown that despite the CpG island hypermethylation observed in virtually all cases of acute myeloid leukemia (AML) with wild-type DNA methyltransferase 3A (DNMT3A), this change was not associated with gene silencing and was essentially absent in AMLs with DNMT3AR882 mutations [24]. This evidence concerns the gene DNMT3A and acute myeloid leukemia.