Also highlighted is the increase in inflammatory cytokines secreted by the immune system and adipose tissue, such as tumor necrosis factor (TNF)-α or interleukin (IL)-1, or by the tumor itself, i.e., specific catabolic factors of proteolysis-inducing factor-type tumors [40], which activate enzymes that induce protein replacement in skeletal muscle. The gene discussed is TNF; the disease is neoplasm.