HSPA5 and cancer: βIII-Tubulin interacts with the master regulator of the ER stress response GRP78 in ovarian and NSCLC cancer cells [138,161] and influences the formation of a complex between AKT and GRP78 in response to glucose starvation [161], raising the possibility that it may play a role in maintaining the protein processing capacity of the ER to support continued cell growth in the harsh tumour microenvironment.