In the light of the above findings, we aimed to synthesize new oxadiazole, thiadiazole, and triazole derivatives and evaluate their in vitro cytotoxic effects on A549 human lung adenocarcinoma and C6 rat glioma cell lines and potential inhibitory effects on gelatinases (MMP-2, MMP-9) and collagenases (MMP-1, MMP-8, MMP-13). This evidence concerns the gene MMP9 and central nervous system cancer.