In the present study, we aimed to find out whether polymorphic variants of the gene coding for TLR2, TLR4 and TLR9 innate receptors, as well as NF-κB1 transcription factor, could be associated with predisposition to rheumatoid arthritis, progression of the disease, and response to anti-TNF treatment. The gene discussed is TLR9; the disease is rheumatoid arthritis.