Currently known MPN‐associated mutations include JAK2, MPL, LNK, CBL, CALR, TET2, ASXL1, IDH1, IDH2, IKZF1 and EZH2 (Table 1: Mutations in epigenetic regulators and their current prognostic value in myeloid malignancies) 36. The gene discussed is EZH2; the disease is myeloproliferative disorder.