While downstream signaling events are mediated primarily via TRAF-6 in atherosclerosis, Donners et al. found that mice with a genetic inhibition of CD40/TRAF-6 signaling did not alter platelet deposition and thrombus formation in an in vitro flow chamber assay (133), suggesting an involvement of TRAF-2/3/5 instead. The gene discussed is TRAF6; the disease is atherosclerosis.