Although treatment with BG9588 and other antihuman CD40L antibodies showed a significant reduction in disease-specific parameters (127, 183), including levels of autoantibodies and renal function, its clinical evaluation was stopped because of an increased rate of thromboembolic events in one study, where two cases of myocardial infarction were recorded (127). This evidence concerns the gene CD40LG and myocardial infarction.