Clinical studies on the role of genetic abnormalities in pneumococcal meningitis showed the association of meningitis with polymorphisms in the inflammasome genes encoding caspase recruitment domain family member 8 (CARD8; SNP ID: rs2043211) and NLR family pyrin domain containing 1 (NLRP1; SNP ID: rs11621270). This evidence concerns the gene NLRP1 and pneumococcal meningitis.