NFKBIE and pneumococcal meningitis: Lundbo and co-workers also found the association of pneumococcal meningitis with the polymorphism of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (NFKBIE) and that the increased risk of invasive pneumococcal disease (IPD) was in the heterozygosity meningitis group for NFKBIE (Lundbo et al., 2016).