Specifically, IL-12 and IFN-γ induce synergistically bacterial clearance from the lungs and pulmonary cellular infiltration during extracellular and intracellular bacterial infection, such as L. monocytogenes, S. pneumonia, Chlamydia muridarum, M. tuberculosis (Haring et al., 2005; Mpiga and Ravaoarinoro, 2006; Sun et al., 2007; Cooper and Khader, 2008; Jupelli et al., 2010; Hashiguchi et al., 2014). This evidence concerns the gene IFNG and bacterial infectious disease.