BDNF is known to play an important role in the regulation of learning and memory (Komulainen et al., 2008; Cowansage et al., 2010; Lu et al., 2014; Tong et al., 2015), and can be used as a therapeutic agent to alleviate cognitive impairment (Wu et al., 2015). The gene discussed is BDNF; the disease is Cognitive impairment.