MAPT and Parkinson disease: Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP) in many candidate genes that contribute to PD susceptibility such as microtubule-associated protein tau (MAPT), leucine-rich repeat kinase (LRRK2) and alpha-synuclein (SNCA) (Mata et al., 2011; Satake et al., 2009; Simón-Sánchez et al., 2009; Sharma et al., 2012).