CCL2 and Alzheimer disease: An array of elevated inflammatory mediators including TNFα, IL-1, PGE2, NF-κB, COX-2 and MCP-1 has been detected from patients with AD (Wyss-Coray, 2006; Comi et al., 2010) and correlated with the amount of Aβ and the severity of AD pathogenesis (Hoshino et al., 2009; Chen et al., 2012).