A potassium ATP dependent channel (KCNJ3, potassium voltage-gated channel subfamily J member 3), which expression is inhibited in bipolar depression and schizophrenia, was down regulated in the Drosophila KD and the gene appeared as part of one of the significant pathways in the human GWAS (Table 2). The gene discussed is KCNJ3; the disease is bipolar disorder.