Related to these calcium channels, mutations in 3 of the genes present in the diagram CACNA1C, CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1) and SCN5A (sodium voltage-gated channel alpha subunit 5) have been shown to cause the Brugada Syndrome, characterized by typical ECG features, ventricular arrhythmias, which may be accompanied by sleep disordered breathing26. The gene discussed is SCN5A; the disease is Ventricular arrhythmia.