CACNA2D1 and Brugada syndrome: Related to these calcium channels, mutations in 3 of the genes present in the diagram CACNA1C, CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1) and SCN5A (sodium voltage-gated channel alpha subunit 5) have been shown to cause the Brugada Syndrome, characterized by typical ECG features, ventricular arrhythmias, which may be accompanied by sleep disordered breathing26.