Our results further suggest that ABCB1-overexpressing MM may likewise have a low sensitivity to other strong ABCB1 substrate drugs used in MM therapy, such as panobinostat or daunorubicin, but may be better targeted with ixazomib, cyclophosphamide or marizomib, which lack significant ABCB1 interaction. Here, ABCB1 is linked to Miyoshi myopathy.