After incorporation of information on sex and the Wells score, receiver operating characteristic (ROC) curves demonstrated comparable diagnostic performance of CRP and D-dimer in patients < 60 years of age for proximal DVT (AUCD-dimer: 0.842 vs. AUCCRP: 0.831) and isolated distal DVT (AUCD-dimer: 0.674 vs. AUCCRP: 0.667) (for both, P for difference > 0.05; Fig. 3). This evidence concerns the gene CRP and deep vein thrombosis.