In patients ≥ 60 years, D-dimer showed a higher AUC in comparison to CRP for proximal DVT (AUCD-dimer: 0.865 vs. AUCCRP: 0.679; P for difference < .001), whereas no statistically-significant difference was detected for isolated distal DVT (AUCD-dimer: 0.622 vs. AUCCRP: 0.604; P for difference = 0.33). This evidence concerns the gene CRP and deep vein thrombosis.