CRP and deep vein thrombosis: Comparison of the diagnostic performance for the optimized fixed thresholds of both biomarkers in patients < 60 years did not result in relevant differences of the diagnostic utility of CRP for proximal DVT (c-indexD-dimer: 0.562 vs. c-indexCRP: 0.543) or isolated distal DVT (c-indexD-dimer: 0.518 vs. c-indexCRP: 0.487) in comparison to D-dimer (Table 3; for both: P for difference > 0.05).